ZFIN is now using GRCz12tu for Genomic Data
Gene
runx3
- ID
- ZDB-GENE-000605-2
- Name
- RUNX family transcription factor 3
- Symbol
- runx3 Nomenclature History
- Previous Names
-
- runxb
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within cartilage development; embryonic viscerocranium morphogenesis; and hemopoiesis. Predicted to be located in nucleus. Is expressed in several structures, including Rohon-Beard neurons; digestive system; ganglia; oral epithelium; and skeletal element. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); female reproductive organ cancer (multiple); lung non-small cell carcinoma; pancreatic cancer; and urinary bladder cancer. Orthologous to human RUNX3 (RUNX family transcription factor 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR013524 | Runt domain |
| Domain | IPR013711 | Runx, C-terminal domain |
| Family | IPR000040 | Acute myeloid leukemia 1 protein (AML1)/Runt |
| Family | IPR016554 | Runt-related transcription factor RUNX |
| Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding domain superfamily |
| Homologous_superfamily | IPR012346 | p53/RUNT-type transcription factor, DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Acute myeloid leukemia 1 protein (AML1)/Runt | p53-like transcription factor, DNA-binding domain superfamily | p53/RUNT-type transcription factor, DNA-binding domain superfamily | Runt domain | Runt-related transcription factor RUNX | Runx, C-terminal domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q9DEA0 | InterPro | 424 | ||||||
| UniProtKB:A0AB32T1U3 | InterPro | 438 | ||||||
| UniProtKB:A0AB32T6V9 | InterPro | 385 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers