ZFIN is now using GRCz12tu for Genomic Data
Gene
gart
- ID
- ZDB-GENE-000616-14
- Name
- phosphoribosylglycinamide formyltransferase
- Symbol
- gart Nomenclature History
- Previous Names
-
- wu:fb33g04 (1)
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable phosphoribosylamine-glycine ligase activity and phosphoribosylformylglycinamidine cyclo-ligase activity. Acts upstream of or within camera-type eye development; chordate embryonic development; and pigmentation. Predicted to be active in cytosol. Is expressed in several structures, including alar plate midbrain region; digestive system; immature eye; nervous system; and yolk syncytial layer. Orthologous to human GART (phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56025 (11 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR001555 | Phosphoribosylglycinamide formyltransferase, active site |
| Conserved_site | IPR020559 | Phosphoribosylglycinamide synthetase, conserved site |
| Domain | IPR002376 | Formyl transferase, N-terminal |
| Domain | IPR010918 | PurM-like, C-terminal domain |
| Domain | IPR011761 | ATP-grasp fold |
| Domain | IPR016188 | PurM-like, N-terminal domain |
| Domain | IPR020560 | Phosphoribosylglycinamide synthetase, C-domain |
| Domain | IPR020561 | Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain |
| Domain | IPR020562 | Phosphoribosylglycinamide synthetase, N-terminal |
| Family | IPR000115 | Phosphoribosylglycinamide synthetase |
| Family | IPR004607 | Phosphoribosylglycinamide formyltransferase |
| Family | IPR004733 | Phosphoribosylformylglycinamidine cyclo-ligase |
| Homologous_superfamily | IPR011054 | Rudiment single hybrid motif |
| Homologous_superfamily | IPR013815 | ATP-grasp fold, subdomain 1 |
| Homologous_superfamily | IPR016185 | Pre-ATP-grasp domain superfamily |
| Homologous_superfamily | IPR036477 | Formyl transferase, N-terminal domain superfamily |
| Homologous_superfamily | IPR036676 | PurM-like, C-terminal domain superfamily |
| Homologous_superfamily | IPR036921 | PurM-like, N-terminal domain superfamily |
| Homologous_superfamily | IPR037123 | Phosphoribosylglycinamide synthetase, C-domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | ATP-grasp fold | ATP-grasp fold, subdomain 1 | Formyl transferase, N-terminal | Formyl transferase, N-terminal domain superfamily | Phosphoribosylformylglycinamidine cyclo-ligase | Phosphoribosylglycinamide formyltransferase | Phosphoribosylglycinamide formyltransferase, active site | Phosphoribosylglycinamide synthetase | Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain | Phosphoribosylglycinamide synthetase, C-domain | Phosphoribosylglycinamide synthetase, C-domain superfamily | Phosphoribosylglycinamide synthetase, conserved site | Phosphoribosylglycinamide synthetase, N-terminal | Pre-ATP-grasp domain superfamily | PurM-like, C-terminal domain | PurM-like, C-terminal domain superfamily | PurM-like, N-terminal domain | PurM-like, N-terminal domain superfamily | Rudiment single hybrid motif |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q9I9E6 | InterPro | 1017 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers