ZFIN is now using GRCz12tu for Genomic Data
Gene
caspa
- ID
- ZDB-GENE-000616-3
- Name
- caspase a
- Symbol
- caspa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables Pyrin domain binding activity and cysteine-type endopeptidase activity. Involved in self proteolysis. Acts upstream of or within several processes, including embryonic viscerocranium morphogenesis; innate immune response; and pyroptotic inflammatory response. Part of NLRP1 inflammasome complex. Is expressed in several structures, including digestive system; heart; hematopoietic system; integument; and male organism. Orthologous to several human genes including CASP4 (caspase 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016129 | Peptidase family C14A, His active site |
| Active_site | IPR033139 | Peptidase family C14A, cysteine active site |
| Domain | IPR001309 | Peptidase C14, p20 domain |
| Domain | IPR002138 | Peptidase C14, caspase non-catalytic subunit p10 |
| Domain | IPR004020 | DAPIN domain |
| Domain | IPR011600 | Peptidase C14, caspase domain |
| Domain | IPR015917 | Peptidase C14A, caspase catalytic domain |
| Family | IPR002398 | Peptidase C14 family |
| Homologous_superfamily | IPR011029 | Death-like domain superfamily |
| Homologous_superfamily | IPR029030 | Caspase-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Caspase-like domain superfamily | DAPIN domain | Death-like domain superfamily | Peptidase C14A, caspase catalytic domain | Peptidase C14, caspase domain | Peptidase C14, caspase non-catalytic subunit p10 | Peptidase C14 family | Peptidase C14, p20 domain | Peptidase family C14A, cysteine active site | Peptidase family C14A, His active site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q9I9L7 | InterPro | 383 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers