ZFIN is now using GRCz12tu for Genomic Data
Gene
gata6
- ID
- ZDB-GENE-000622-1
- Name
- GATA binding protein 6
- Symbol
- gata6 Nomenclature History
- Previous Names
-
- GATA-5
- cb603 (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables DNA binding activity. Acts upstream of or within several processes, including cardioblast migration to the midline involved in heart field formation; liver development; and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including blastoderm; cardiovascular system; digestive system; mesoderm; and yolk syncytial layer. Human ortholog(s) of this gene implicated in adenocarcinoma (multiple); congenital heart disease (multiple); and pancreatic hypoplasia-diabetes-congenital heart disease syndrome. Orthologous to human GATA6 (GATA binding protein 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 93 figures from 68 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb603 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| atrial heart septal defect 9 | Alliance | Atrial septal defect 9 | 614475 |
| atrioventricular septal defect | Alliance | Atrioventricular septal defect 5 | 614474 |
| double outlet right ventricle | Alliance | Persistent truncus arteriosus | 217095 |
| pancreatic hypoplasia-diabetes-congenital heart disease syndrome | Alliance | Pancreatic agenesis and congenital heart defects | 600001 |
| tetralogy of Fallot | Alliance | Tetralogy of Fallot | 187500 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | GATA-type transcription activator, N-terminal | Transcription factor GATA | Zinc finger, GATA-type | Zinc finger, NHR/GATA-type |
|---|---|---|---|---|---|---|
| UniProtKB:Q6NW63 | InterPro | 501 | ||||
| UniProtKB:A0A8M6Z1Y8 | InterPro | 496 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers