ZFIN is now using GRCz12tu for Genomic Data
Gene
robo2
- ID
- ZDB-GENE-001019-1
- Name
- roundabout, axon guidance receptor, homolog 2 (Drosophila)
- Symbol
- robo2 Nomenclature History
- Previous Names
-
- ast
- astray
- sb:eu937
- unp1881
- zmp:0000000549 (1)
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable identical protein binding activity. Involved in negative regulation of synapse assembly. Acts upstream of or within several processes, including axon development; regulation of extent of cell growth; and sensory perception of touch. Predicted to be located in cell surface. Is expressed in several structures, including digestive system; dorsal fin; nervous system; spleen; and trigeminal placode. Human ortholog(s) of this gene implicated in vesicoureteral reflux. Orthologous to human ROBO2 (roundabout guidance receptor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 36 figures from 24 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu937 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- 30 figures from 14 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| vesicoureteral reflux | Alliance | Vesicoureteral reflux 2 | 610878 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR013098 | Immunoglobulin I-set |
| Domain | IPR013106 | Immunoglobulin V-set domain |
| Family | IPR051170 | Neural and epithelial cell adhesion domain-containing protein |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Domain Details Per Protein
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers
- Comparative Orthology
- Alliance