prss1

ID

ZDB-GENE-010131-7

Name

serine protease 1

Symbol

prss1 Nomenclature History

Previous Names

try (1)
trypsin (1)
wu:fb57g08 (1)
zgc:109701

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in acinar cell; brain; digestive system; exocrine cell; and heart. Human ortholog(s) of this gene implicated in pancreatitis. Orthologous to several human genes including PRSS1 (serine protease 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

170 figures from 104 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:109701 (2 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With prss1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
pancreatitis	Alliance	Pancreatitis, hereditary	167800

Associated With prss1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR018114	Serine proteases, trypsin family, histidine active site
Active_site	IPR033116	Serine proteases, trypsin family, serine active site
Domain	IPR001254	Serine proteases, trypsin domain
Family	IPR001314	Peptidase S1A, chymotrypsin family
Family	IPR050127	Serine Proteases (Peptidase S1 Family)
Homologous_superfamily	IPR009003	Peptidase S1, PA clan
Homologous_superfamily	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold