ZFIN is now using GRCz12tu for Genomic Data
Gene
spry4
- ID
- ZDB-GENE-010803-2
- Name
- sprouty homolog 4 (Drosophila)
- Symbol
- spry4 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Acts upstream of or within several processes, including negative regulation of fibroblast growth factor receptor signaling pathway; rhombomere formation; and skeletal muscle fiber development. Predicted to be located in membrane. Predicted to be active in cytosol. Is expressed in several structures, including immature eye; mesoderm; nervous system; neural keel; and neural plate. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 17 with or without anosmia. Orthologous to human SPRY4 (sprouty RTK signaling antagonist 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 55 figures from 44 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb511 (49 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypogonadotropic hypogonadism 17 with or without anosmia | Alliance | Hypogonadotropic hypogonadism 17 with or without anosmia | 615266 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Sprouty | Sprouty domain-containing protein |
|---|---|---|---|---|
| UniProtKB:A0A8M9PQ80 | InterPro | 310 | ||
| UniProtKB:Q90XH4 | InterPro | 310 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
- Genome Browsers