Gene
ache
- ID
- ZDB-GENE-010906-1
- Name
- acetylcholinesterase (Yt blood group)
- Symbol
- ache Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Enables acetylcholinesterase activity. Acts upstream of or within several processes, including acetylcholine catabolic process; cellular response to methanol; and nervous system development. Predicted to be located in extracellular region and synapse. Predicted to be active in extracellular space and plasma membrane. Is expressed in several structures, including female organism; male organism; muscle; nervous system; and neural tube. Human ortholog(s) of this gene implicated in Alzheimer's disease; drug dependence (multiple); epilepsy; myasthenia gravis; and subacute delirium. Orthologous to human ACHE (acetylcholinesterase (Yt blood group)).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 31 figures from 21 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu3 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- 24 figures from 11 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| [Blood group, Yt system] | 112100 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR019826 | Carboxylesterase type B, active site |
| Conserved_site | IPR019819 | Carboxylesterase type B, conserved site |
| Domain | IPR002018 | Carboxylesterase, type B |
| Domain | IPR014788 | Acetylcholinesterase, tetramerisation domain |
| Family | IPR000997 | Cholinesterase |
| Family | IPR050654 | Acetylcholinesterase-related enzymes |
| Homologous_superfamily | IPR029058 | Alpha/Beta hydrolase fold |
Domain Details Per Protein
| Protein | Additional Resources | Length | Acetylcholinesterase-related enzymes | Acetylcholinesterase, tetramerisation domain | Alpha/Beta hydrolase fold | Carboxylesterase, type B | Carboxylesterase type B, active site | Carboxylesterase type B, conserved site | Cholinesterase |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:B3DKL4 | InterPro | 634 | |||||||
| UniProtKB:Q9DDE3 | InterPro | 634 |
Interactions and Pathways
No data available
Plasmids
No data available