Gene
tfe3b
- ID
- ZDB-GENE-010919-3
- Name
- transcription factor binding to IGHM enhancer 3b
- Symbol
- tfe3b Nomenclature History
- Previous Names
-
- si:dkey-13a21.9
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including digestive system; ionocyte; lens placode; polster; and sensory system. Human ortholog(s) of this gene implicated in renal cell carcinoma. Orthologous to human TFE3 (transcription factor binding to IGHM enhancer 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu646 (2 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| renal cell carcinoma | Alliance | Renal cell carcinoma, papillary, 1 | 300854 |
| Intellectual developmental disorder, X-linked syndromic, with pigmentary mosaicism and coarse facies | 301066 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
| Domain | IPR021802 | MiT/TFE transcription factors, C-terminal |
| Domain | IPR024100 | Transcription factor E3, bHLHzip domain |
| Domain | IPR031867 | MiT/TFE transcription factors, N-terminal |
| Homologous_superfamily | IPR036638 | Helix-loop-helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Helix-loop-helix DNA-binding domain superfamily | MiT/TFE transcription factors, C-terminal | MiT/TFE transcription factors, N-terminal | Myc-type, basic helix-loop-helix (bHLH) domain | Transcription factor E3, bHLHzip domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BGM5 | InterPro | 445 | |||||
| UniProtKB:F1R1N1 | InterPro | 451 | |||||
| UniProtKB:A0A8M6Z8P2 | InterPro | 294 | |||||
| UniProtKB:Q7SZX8 | InterPro | 451 | |||||
| UniProtKB:A0A8M2BGP5 | InterPro | 449 | |||||
| UniProtKB:A0A8M3B427 | InterPro | 447 | |||||
| UniProtKB:A0A8M2BH69 | InterPro | 443 |
Interactions and Pathways
No data available
Plasmids