ZFIN is now using GRCz12tu for Genomic Data
Gene
cebpa
- ID
- ZDB-GENE-020111-2
- Name
- CCAAT enhancer binding protein alpha
- Symbol
- cebpa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within hematopoietic stem cell migration; hemopoiesis; and liver development. Predicted to be located in nucleus. Is expressed in several structures, including adipose tissue; digestive system; hematopoietic cell; hematopoietic system; and mesoderm. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human CEBPA (CCAAT enhancer binding protein alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 67 figures from 52 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1062 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acute myeloid leukemia | Alliance | Leukemia, acute myeloid, somatic | 601626 |
| acute myeloid leukemia | Alliance | ?Leukemia, acute myeloid | 601626 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Basic-leucine zipper domain | Basic-leucine zipper domain superfamily | CCAAT/enhancer-binding protein C/EBP | CCAAT/enhancer-binding protein, chordates |
|---|---|---|---|---|---|---|
| UniProtKB:Q8UVZ1 | InterPro | 288 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
- Genome Browsers