Gene

mycn

ID

ZDB-GENE-020711-1

Name

MYCN proto-oncogene, bHLH transcription factor

Symbol

mycn Nomenclature History

Previous Names

N-myc (1)
fb57a02 (1)
nmyc1 (1)
wu:fb57a02 (1)
zgc:85706 (1)
zN-myc (1)

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to enable DNA binding activity. Predicted to be involved in hematopoietic progenitor cell differentiation. Predicted to be located in nucleus. Is expressed in several structures, including immature eye; nervous system; pectoral fin bud; pharyngeal arch; and vagal neural crest. Human ortholog(s) of this gene implicated in Feingold syndrome. Orthologous to human MYCN (MYCN proto-oncogene, bHLH transcription factor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

15 figures from 14 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mycn Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Feingold syndrome	Alliance	Feingold syndrome 1	164280
		Megalencephaly-polydactyly syndrome	620748

Associated With mycn Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Domain	IPR012682	Transcription regulator Myc, N-terminal
Family	IPR002418	Transcription regulator Myc
Family	IPR050433	Myc family transcription factors
Homologous_superfamily	IPR036638	Helix-loop-helix DNA-binding domain superfamily