ZFIN is now using GRCz12tu for Genomic Data
Gene
nkx3-2
- ID
- ZDB-GENE-030127-1
- Name
- NK3 homeobox 2
- Symbol
- nkx3-2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within bone morphogenesis; embryonic skeletal joint morphogenesis; and embryonic viscerocranium morphogenesis. Predicted to be active in nucleus. Is expressed in several structures, including neuromast; notochord; pharyngeal arch; pharyngeal endoderm; and skeletal system. Orthologous to human NKX3-2 (NK3 homeobox 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 44 figures from 31 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu470 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- 25 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Spondylo-megaepiphyseal-metaphyseal dysplasia | 613330 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeobox NK-like transcription regulators | Homeodomain | Homeodomain, metazoa |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q803Z6 | InterPro | 245 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nkx3.2-201
(1)
|
Ensembl | 1,964 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers