Gene
apoa4b.1
- ID
- ZDB-GENE-030131-1263
- Name
- apolipoprotein A-IV b, tandem duplicate 1
- Symbol
- apoa4b.1 Nomenclature History
- Previous Names
-
- Apo A-IV (1)
- apoa4
- wu:fb64f03
- wu:fb66f09
- zgc:122983
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable cholesterol transfer activity; phosphatidylcholine-sterol O-acyltransferase activator activity; and phospholipid binding activity. Predicted to be involved in several processes, including acylglycerol homeostasis; cholesterol efflux; and phospholipid efflux. Predicted to be located in extracellular region. Predicted to be part of several cellular components, including chylomicron; low-density lipoprotein particle; and very-low-density lipoprotein particle. Predicted to be active in extracellular vesicle. Is expressed in female organism; gut; liver; and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant tubulointerstitial kidney disease 6; colitis (multiple); coronary artery disease (multiple); familial hyperlipidemia (multiple); and type 2 diabetes mellitus. Orthologous to several human genes including APOA4 (apolipoprotein A4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 26 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6908289 (6 images)
- IMAGE:6910484 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant tubulointerstitial kidney disease 6 | Alliance | Tubulointerstitial kidney disease, autosomal dominant 6 | 621106 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Apolipoprotein A1/A4/E | Apolipoprotein A/E |
|---|---|---|---|---|
| UniProtKB:Q3B7G4 | InterPro | 255 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
apoa4b.1-201
(1)
|
Ensembl | 1,202 nt | ||
| mRNA |
apoa4b.1-203
(1)
|
Ensembl | 1,716 nt | ||
| ncRNA |
apoa4b.1-002
(1)
|
Ensembl | 417 nt |
Interactions and Pathways
No data available
Plasmids