Gene
apoa4b.2
- ID
- ZDB-GENE-030131-3143
- Name
- apolipoprotein A-IV b, tandem duplicate 2
- Symbol
- apoa4b.2 Nomenclature History
- Previous Names
-
- fc28d04
- wu:fc10a03
- wu:fc28d04 (1)
- zgc:194131
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable cholesterol transfer activity; phosphatidylcholine-sterol O-acyltransferase activator activity; and phospholipid binding activity. Predicted to be involved in several processes, including acylglycerol homeostasis; cholesterol efflux; and phospholipid efflux. Predicted to be located in extracellular region. Predicted to be part of several cellular components, including chylomicron; low-density lipoprotein particle; and very-low-density lipoprotein particle. Predicted to be active in extracellular vesicle. Is expressed in ball; extension; intestine; yolk; and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant tubulointerstitial kidney disease 6; colitis (multiple); coronary artery disease (multiple); familial hyperlipidemia (multiple); and type 2 diabetes mellitus. Orthologous to several human genes including APOA4 (apolipoprotein A4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant tubulointerstitial kidney disease 6 | Alliance | Tubulointerstitial kidney disease, autosomal dominant 6 | 621106 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Apolipoprotein A1/A4/E | Apolipoprotein A/E |
|---|---|---|---|---|
| UniProtKB:A0A8M9NZC6 | InterPro | 314 | ||
| UniProtKB:B3DHC5 | InterPro | 255 | ||
| UniProtKB:F1QJD1 | InterPro | 255 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
apoa4b.2-201
(1)
|
Ensembl | 970 nt | ||
| mRNA |
apoa4b.2-202
(1)
|
Ensembl | 811 nt | ||
| mRNA |
apoa4b.2-203
(1)
|
Ensembl | 1,046 nt | ||
| mRNA |
apoa4b.2-204
(1)
|
Ensembl | 588 nt | ||
| ncRNA |
apoa4b.2-002
(1)
|
Ensembl | 617 nt |
Interactions and Pathways
No data available
Plasmids