ZFIN is now using GRCz12tu for Genomic Data
Gene
tp53bp1
- ID
- ZDB-GENE-030131-3695
- Name
- tumor protein p53 binding protein, 1
- Symbol
- tp53bp1 Nomenclature History
- Previous Names
-
- wu:fc50a09
- wu:fj67d04
- zgc:158452
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable histone binding activity. Predicted to be involved in DNA damage checkpoint signaling and positive regulation of transcription by RNA polymerase II. Predicted to be located in kinetochore; nuclear body; and site of double-strand break. Predicted to be active in nucleus. Orthologous to human TP53BP1 (tumor protein p53 binding protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Yang et al., 2019
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001357 | BRCT domain |
| Domain | IPR015125 | Tumour suppressor p53-binding protein-1, Tudor domain |
| Domain | IPR047249 | TP53-binding protein 1-like, first BRCT domain |
| Domain | IPR047250 | TP53-binding protein 1-like, second BRCT domain |
| Family | IPR047252 | TP53-binding protein 1-like |
| Homologous_superfamily | IPR014722 | Large ribosomal subunit protein uL2, domain 2 |
| Homologous_superfamily | IPR036420 | BRCT domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | BRCT domain | BRCT domain superfamily | Large ribosomal subunit protein uL2, domain 2 | TP53-binding protein 1-like | TP53-binding protein 1-like, first BRCT domain | TP53-binding protein 1-like, second BRCT domain | Tumour suppressor p53-binding protein-1, Tudor domain |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M6Z753 | InterPro | 1762 | |||||||
| UniProtKB:A1L1W2 | InterPro | 1709 | |||||||
| UniProtKB:A0A8M6Z7P8 | InterPro | 1499 | |||||||
| UniProtKB:A0A8M6Z1I8 | InterPro | 1642 | |||||||
| UniProtKB:A0A8M6YZZ7 | InterPro | 1754 | |||||||
| UniProtKB:A0A8M9PNZ2 | InterPro | 1636 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tp53bp1-201
(1)
|
Ensembl | 5,546 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers