ZFIN is now using GRCz12tu for Genomic Data
Gene
vegfab
- ID
- ZDB-GENE-030131-4605
- Name
- vascular endothelial growth factor Ab
- Symbol
- vegfab Nomenclature History
- Previous Names
-
- fd42e02 (1)
- si:dkey-14d8.3
- wu:fd42e02
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable chemoattractant activity; growth factor activity; and vascular endothelial growth factor receptor binding activity. Acts upstream of or within sprouting angiogenesis. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in brain; head; pronephros; and vasculature. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human VEGFA (vascular endothelial growth factor A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 25 figures from 22 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Microvascular complications of diabetes 1} | 603933 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR023581 | Platelet-derived growth factor, conserved site |
| Domain | IPR000072 | PDGF/VEGF domain |
| Domain | IPR027928 | Vascular endothelial growth factor, heparin-binding domain |
| Family | IPR050507 | Platelet-derived/Vascular endothelial growth factor |
| Homologous_superfamily | IPR029034 | Cystine-knot cytokine |
| Homologous_superfamily | IPR036841 | Vascular endothelial growth factor, heparin-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Cystine-knot cytokine | PDGF/VEGF domain | Platelet-derived growth factor, conserved site | Platelet-derived/Vascular endothelial growth factor | Vascular endothelial growth factor, heparin-binding domain | Vascular endothelial growth factor, heparin-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BBS4 | InterPro | 250 | ||||||
| UniProtKB:Q0QYI0 | InterPro | 194 | ||||||
| UniProtKB:A0A8M3B1G0 | InterPro | 227 | ||||||
| UniProtKB:A0A8M1P9F8 | InterPro | 252 | ||||||
| UniProtKB:A0AB32TK28 | InterPro | 249 | ||||||
| UniProtKB:A0AB32TK78 | InterPro | 285 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
vegfab-201
(1)
|
Ensembl | 600 nt | ||
| mRNA |
vegfab-202
(1)
|
Ensembl | 2,198 nt | ||
| mRNA |
vegfab-203
(1)
|
Ensembl | 2,227 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers