ZFIN is now using GRCz12tu for Genomic Data
Gene
ctsa
- ID
- ZDB-GENE-030131-537
- Name
- cathepsin A
- Symbol
- ctsa Nomenclature History
- Previous Names
-
- wu:fb33g02
- wu:fb36c08
- wu:fj91g05
- zgc:65802
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable serine-type carboxypeptidase activity. Predicted to be involved in negative regulation of chaperone-mediated autophagy; proteolysis; and regulation of protein stability. Is expressed in brain and muscle. Human ortholog(s) of this gene implicated in galactosialidosis and lysosomal storage disease. Orthologous to human CTSA (cathepsin A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7146565 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| galactosialidosis | Alliance | Galactosialidosis | 256540 |
| Brain small vessel disease 6 with leukoencephalopathy | 621394 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Alpha/Beta hydrolase fold | Peptidase S10, serine carboxypeptidase | Serine carboxypeptidase, serine active site | Serine carboxypeptidases, histidine active site |
|---|---|---|---|---|---|---|
| UniProtKB:Q6PHJ3 | InterPro | 471 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers