ZFIN is now using GRCz12tu for Genomic Data
Gene
ercc4
- ID
- ZDB-GENE-030131-5533
- Name
- excision repair cross-complementation group 4
- Symbol
- ercc4 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable damaged DNA binding activity and single-stranded DNA binding activity. Predicted to contribute to 3' overhang single-stranded DNA endodeoxyribonuclease activity. Predicted to be involved in DNA metabolic process. Predicted to act upstream of or within DNA damage response. Predicted to be located in chromosome and nucleus. Predicted to be part of nucleotide-excision repair factor 1 complex. Is expressed in liver. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group Q; XFE progeroid syndrome; pancreatic cancer; polyneuropathy due to drug; and xeroderma pigmentosum (multiple). Orthologous to human ERCC4 (ERCC excision repair 4, endonuclease catalytic subunit).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Ramanagoudr-Bhojappa et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Fanconi anemia complementation group Q | Alliance | Fanconi anemia, complementation group Q | 615272 |
| xeroderma pigmentosum group F | Alliance | Xeroderma pigmentosum, group F | 278760 |
| xeroderma pigmentosum group F | Alliance | Xeroderma pigmentosum, type F/Cockayne syndrome | 278760 |
| XFE progeroid syndrome | Alliance | XFE progeroid syndrome | 610965 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | DNA repair endonuclease XPF, nuclease domain | DNA repair protein XPF | ERCC4 domain | Restriction endonuclease type II-like | RuvA domain 2-like |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q7SYE8 | InterPro | 886 | |||||
| UniProtKB:A0AB32U361 | InterPro | 886 | |||||
| UniProtKB:A0AC58GUY5 | InterPro | 886 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers