ZFIN is now using GRCz12tu for Genomic Data
Gene
kif14
- ID
- ZDB-GENE-030131-5759
- Name
- kinesin family member 14
- Symbol
- kif14 Nomenclature History
- Previous Names
-
- si:dkey-39e8.3
- wu:fi16h07
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Acts upstream of or within brain development and kidney development. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm and microtubule. Human ortholog(s) of this gene implicated in Meckel syndrome and primary autosomal recessive microcephaly 20. Orthologous to human KIF14 (kinesin family member 14).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2005
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu1117 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Reilly et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary autosomal recessive microcephaly 20 | Alliance | Microcephaly 20, primary, autosomal recessive | 617914 |
| ?Meckel syndrome 12 | 616258 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019821 | Kinesin motor domain, conserved site |
| Domain | IPR000253 | Forkhead-associated (FHA) domain |
| Domain | IPR001752 | Kinesin motor domain |
| Domain | IPR032405 | Kinesin-associated |
| Domain | IPR056523 | KIF14, four-helical bundle |
| Homologous_superfamily | IPR008984 | SMAD/FHA domain superfamily |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Forkhead-associated (FHA) domain | KIF14, four-helical bundle | Kinesin-associated | Kinesin motor domain | Kinesin motor domain, conserved site | Kinesin motor domain superfamily | P-loop containing nucleoside triphosphate hydrolase | SMAD/FHA domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q1LW14 | InterPro | 1307 | ||||||||
| UniProtKB:F1Q554 | InterPro | 1506 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers