ZFIN is now using GRCz12tu for Genomic Data
Gene
rnf146
- ID
- ZDB-GENE-030131-5997
- Name
- ring finger protein 146
- Symbol
- rnf146 Nomenclature History
- Previous Names
-
- wu:fi29e08
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable poly-ADP-D-ribose binding activity and ubiquitin-protein transferase activity. Predicted to be involved in positive regulation of canonical Wnt signaling pathway; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in female organism. Orthologous to human RNF146 (ring finger protein 146).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Newman et al., 2019
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017907 | Zinc finger, RING-type, conserved site |
| Domain | IPR001841 | Zinc finger, RING-type |
| Domain | IPR004170 | WWE domain |
| Domain | IPR018123 | WWE domain, subgroup |
| Domain | IPR044110 | RNF146, RING finger, HC subclass |
| Family | IPR033509 | E3 ubiquitin-protein ligase RNF146 |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR037197 | WWE domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | E3 ubiquitin-protein ligase RNF146 | RNF146, RING finger, HC subclass | WWE domain | WWE domain, subgroup | WWE domain superfamily | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type | Zinc finger, RING-type, conserved site |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1R5P0 | InterPro | 364 | ||||||||
| UniProtKB:Q7ZUK0 | InterPro | 364 | ||||||||
| UniProtKB:A0AC58IIX9 | InterPro | 364 | ||||||||
| UniProtKB:A0AC58IIY5 | InterPro | 364 | ||||||||
| UniProtKB:A0AC58IJ27 | InterPro | 364 | ||||||||
| UniProtKB:A0AC58IJ38 | InterPro | 364 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
rnf146-202
(1)
|
Ensembl | 4,004 nt | ||
| mRNA |
rnf146-203
(1)
|
Ensembl | 765 nt | ||
| mRNA |
rnf146-204
(1)
|
Ensembl | 2,924 nt | ||
| ncRNA |
rnf146-003
(1)
|
Ensembl | 804 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers