Gene
st14a
- ID
- ZDB-GENE-030131-6496
- Name
- ST14 transmembrane serine protease matriptase a
- Symbol
- st14a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Enables peptidase activity. Involved in protein processing. Acts upstream of or within cell aggregation and epidermis development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in epidermis; gut; lateral line primordium; otic vesicle; and primitive olfactory epithelium. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 11. Orthologous to human ST14 (ST14 transmembrane serine protease matriptase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive congenital ichthyosis 11 | Alliance | Ichthyosis, congenital, autosomal recessive 11 | 602400 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR018114 | Serine proteases, trypsin family, histidine active site |
| Active_site | IPR033116 | Serine proteases, trypsin family, serine active site |
| Conserved_site | IPR023415 | Low-density lipoprotein (LDL) receptor class A, conserved site |
| Domain | IPR000082 | SEA domain |
| Domain | IPR000859 | CUB domain |
| Domain | IPR001254 | Serine proteases, trypsin domain |
| Family | IPR017051 | Peptidase S1A, matripase |
| Homologous_superfamily | IPR009003 | Peptidase S1, PA clan |
| Homologous_superfamily | IPR035914 | Spermadhesin, CUB domain superfamily |
| Homologous_superfamily | IPR036055 | LDL receptor-like superfamily |
| Homologous_superfamily | IPR036364 | SEA domain superfamily |
| Homologous_superfamily | IPR043504 | Peptidase S1, PA clan, chymotrypsin-like fold |
| Repeat | IPR002172 | Low-density lipoprotein (LDL) receptor class A repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | CUB domain | LDL receptor-like superfamily | Low-density lipoprotein (LDL) receptor class A, conserved site | Low-density lipoprotein (LDL) receptor class A repeat | Peptidase S1A, matripase | Peptidase S1, PA clan | Peptidase S1, PA clan, chymotrypsin-like fold | SEA domain | SEA domain superfamily | Serine proteases, trypsin domain | Serine proteases, trypsin family, histidine active site | Serine proteases, trypsin family, serine active site | Spermadhesin, CUB domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q1RLP8 | InterPro | 827 | |||||||||||||
| UniProtKB:A0A8M9P160 | InterPro | 833 | |||||||||||||
| UniProtKB:A0A8M1N8U6 | InterPro | 834 | |||||||||||||
| UniProtKB:A5PMY0 | InterPro | 834 |
Interactions and Pathways
No data available
Plasmids
No data available