ZFIN is now using GRCz12tu for Genomic Data

Gene

picalmb

ID

ZDB-GENE-030131-6795

Name

phosphatidylinositol binding clathrin assembly protein b

Symbol

picalmb Nomenclature History

Previous Names

picalm
picalml
fa01d03
wu:fa01d03 (1)
wu:fa05d03
wu:fb69g01
wu:fe17e02
zgc:91993

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable SNARE binding activity; clathrin heavy chain binding activity; and phosphatidylinositol binding activity. Predicted to be involved in clathrin-dependent endocytosis and vesicle budding from membrane. Predicted to act upstream of or within clathrin coat assembly. Predicted to be located in several cellular components, including Golgi apparatus; nucleus; and vesicle. Predicted to be active in clathrin-coated pit; clathrin-coated vesicle; and synaptic vesicle. Predicted to be extrinsic component of presynaptic endocytic zone membrane. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human PICALM (phosphatidylinositol binding clathrin assembly protein).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6911564 (1 image)
MGC:91993 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With picalmb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
acute myeloid leukemia	Alliance	Leukemia, acute myeloid, somatic	601626

Associated With picalmb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR011417	AP180 N-terminal homology (ANTH) domain
Domain	IPR013809	ENTH domain
Family	IPR045192	Clathrin coat assembly protein AP180-like
Homologous_superfamily	IPR008942	ENTH/VHS
Homologous_superfamily	IPR014712	ANTH domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M3APS6	InterPro	651
UniProtKB:Q6AXI5	InterPro	590
UniProtKB:A0A8M3B104	InterPro	701
UniProtKB:A0A8M6ZA05	InterPro	702
UniProtKB:A0A8M3APR9	InterPro	729
UniProtKB:A0A8M6Z9M1	InterPro	730
UniProtKB:A0A8M3B110	InterPro	616
UniProtKB:A0A8M3AHC4	InterPro	621
UniProtKB:A0A8M3ASP1	InterPro	672
UniProtKB:A0A8M3AIH0	InterPro	667
UniProtKB:A0A8M3AIG6	InterPro	700
UniProtKB:A0A8M3AHB8	InterPro	725
UniProtKB:A0A8M6Z2V9	InterPro	726
UniProtKB:A0A8M6Z4D6	InterPro	704
UniProtKB:A0AB32T3K3	InterPro	671
UniProtKB:A0AB32T502	InterPro	625
UniProtKB:A0AB32T573	InterPro	620
UniProtKB:A0AB32T8L7	InterPro	646
UniProtKB:A0AC58HAN1	InterPro	700
UniProtKB:A0AC58HAN4	InterPro	703
UniProtKB:A0AC58HAN8	InterPro	698
UniProtKB:A0AC58HAN9	InterPro	695
UniProtKB:A0AC58HAP0	InterPro	696
UniProtKB:A0AC58HAP2	InterPro	674
UniProtKB:A0AC58HAP3	InterPro	697
UniProtKB:A0AC58HAP5	InterPro	675
UniProtKB:A0AC58HAP6	InterPro	676
UniProtKB:A0AC58HAP7	InterPro	699
UniProtKB:A0AC58HAP8	InterPro	668
UniProtKB:A0AC58HAP9	InterPro	669
UniProtKB:A0AC58HAQ2	InterPro	670
UniProtKB:A0AC58HAQ3	InterPro	646
UniProtKB:A0AC58HAQ4	InterPro	641
UniProtKB:A0AC58HAQ5	InterPro	624
UniProtKB:A0AC58HAQ6	InterPro	699
UniProtKB:A0AC58HAQ7	InterPro	645
UniProtKB:A0AC58HAQ8	InterPro	617
UniProtKB:A0AC58HAQ9	InterPro	671
UniProtKB:A0AC58HAR0	InterPro	621
UniProtKB:A0AC58HAR1	InterPro	672
UniProtKB:A0AC58HAR2	InterPro	620
UniProtKB:A0AC58HAR4	InterPro	673
UniProtKB:A0AC58HAR5	InterPro	647
UniProtKB:A0AC58HAR7	InterPro	650
UniProtKB:A0AC58HAS1	InterPro	591
UniProtKB:A0AC58HAS6	InterPro	594
UniProtKB:A0AC58HAT0	InterPro	595

Transcripts

Genome Browsers

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	picalmb-203 (1) Ensembl	Ensembl	1,634 nt	Select Tool ZFIN BLAST
mRNA	picalmb-205 (1) Ensembl	Ensembl	4,903 nt	Select Tool ZFIN BLAST
mRNA	picalmb-206 (1) Ensembl	Ensembl	5,105 nt	Select Tool ZFIN BLAST
ncRNA	picalmb-002 (1) Ensembl	Ensembl	627 nt	Select Tool ZFIN BLAST
ncRNA	picalmb-003 (1) Ensembl	Ensembl	537 nt	Select Tool ZFIN BLAST
ncRNA	picalmb-004 (1) Ensembl	Ensembl	161 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Genome Browsers

NCBI Map Viewer

ZFIN

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations