Gene

mdm4

ID

ZDB-GENE-030131-6872

Name

MDM4 regulator of p53

Symbol

mdm4 Nomenclature History

Previous Names

wu:fa09h09
wu:fi33d10

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein ubiquitination. Predicted to be located in nucleus. Is expressed in brain and post-vent region. Orthologous to human MDM4 (MDM4 regulator of p53).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:113995 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mdm4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		?Bone marrow failure syndrome 6	618849

Associated With mdm4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001876	Zinc finger, RanBP2-type
Domain	IPR003121	SWIB/MDM2 domain
Family	IPR015458	MDM4
Family	IPR016495	p53 negative regulator Mdm2/Mdm4
Family	IPR051652	MDM2/MDM4 and MUL1
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily	IPR036443	Zinc finger, RanBP2-type superfamily
Homologous_superfamily	IPR036885	SWIB/MDM2 domain superfamily