ZFIN is now using GRCz12tu for Genomic Data
Gene
cth
- ID
- ZDB-GENE-030131-774
- Name
- cystathionase (cystathionine gamma-lyase)
- Symbol
- cth Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable cystathionine gamma-lyase activity and pyridoxal phosphate binding activity. Predicted to be involved in L-cysteine biosynthetic process and transsulfuration. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and cystathioninuria. Orthologous to human CTH (cystathionine gamma-lyase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66001 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Kumai et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cystathioninuria | Alliance | Cystathioninuria | 219500 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR054542 | Cys/Met metabolism enzyme, pyridoxal-phosphate attachment site |
| Family | IPR000277 | Cys/Met metabolism, pyridoxal phosphate-dependent enzyme |
| Homologous_superfamily | IPR015421 | Pyridoxal phosphate-dependent transferase, major domain |
| Homologous_superfamily | IPR015422 | Pyridoxal phosphate-dependent transferase, small domain |
| Homologous_superfamily | IPR015424 | Pyridoxal phosphate-dependent transferase |
Domain Details Per Protein
| Protein | Additional Resources | Length | Cys/Met metabolism enzyme, pyridoxal-phosphate attachment site | Cys/Met metabolism, pyridoxal phosphate-dependent enzyme | Pyridoxal phosphate-dependent transferase | Pyridoxal phosphate-dependent transferase, major domain | Pyridoxal phosphate-dependent transferase, small domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:F1QPF7 | InterPro | 404 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers