cdh15

ID

ZDB-GENE-030131-780

Name

cadherin 15, type 1, M-cadherin (myotubule)

Symbol

cdh15 Nomenclature History

Previous Names

fb48f12
wu:fb48f12

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable beta-catenin binding activity and cadherin binding activity. Predicted to be involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell-cell adhesion mediated by cadherin; and cell-cell junction organization. Predicted to act upstream of or within homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to be located in anchoring junction and plasma membrane. Predicted to be part of catenin complex. Predicted to be active in adherens junction. Is expressed in adaxial cell; musculature system; pectoral fin; and somite. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 3. Orthologous to human CDH15 (cadherin 15).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

14 figures from 7 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu141 (10 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Cortés et al., 2003
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cdh15 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant intellectual developmental disorder 3	Alliance	Intellectual developmental disorder, autosomal dominant 3	612580

Associated With cdh15 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020894	Cadherin conserved site
Domain	IPR000233	Cadherin, Y-type LIR-motif
Domain	IPR002126	Cadherin-like
Family	IPR039808	Cadherin
Homologous_superfamily	IPR015919	Cadherin-like superfamily
Homologous_superfamily	IPR027397	Catenin binding domain superfamily