Gene
got2b
- ID
- ZDB-GENE-030131-7917
- Name
- glutamic-oxaloacetic transaminase 2b, mitochondrial
- Symbol
- got2b Nomenclature History
- Previous Names
-
- fj40h07
- wu:fj40h07
- zgc:56425
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable L-aspartate:2-oxoglutarate aminotransferase activity. Predicted to be involved in L-aspartate catabolic process. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in several structures, including adaxial cell; cardiovascular system; musculature system; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 82. Orthologous to human GOT2 (glutamic-oxaloacetic transaminase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56425 (20 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental and epileptic encephalopathy 82 | Alliance | Developmental and epileptic encephalopathy 82 | 618721 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR004838 | Aminotransferases, class-I, pyridoxal-phosphate-binding site |
| Domain | IPR004839 | Aminotransferase, class I/classII, large domain |
| Family | IPR000796 | Aspartate/other aminotransferase |
| Homologous_superfamily | IPR015421 | Pyridoxal phosphate-dependent transferase, major domain |
| Homologous_superfamily | IPR015422 | Pyridoxal phosphate-dependent transferase, small domain |
| Homologous_superfamily | IPR015424 | Pyridoxal phosphate-dependent transferase |
Domain Details Per Protein
| Protein | Additional Resources | Length | Aminotransferase, class I/classII, large domain | Aminotransferases, class-I, pyridoxal-phosphate-binding site | Aspartate/other aminotransferase | Pyridoxal phosphate-dependent transferase | Pyridoxal phosphate-dependent transferase, major domain | Pyridoxal phosphate-dependent transferase, small domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7ZWF5 | InterPro | 428 |
Interactions and Pathways
No data available
Plasmids
No data available