ZFIN is now using GRCz12tu for Genomic Data
Gene
xpc
- ID
- ZDB-GENE-030131-8461
- Name
- xeroderma pigmentosum, complementation group C
- Symbol
- xpc Nomenclature History
- Previous Names
-
- wu:fb12d05
- wu:fb12d09
- zgc:113032
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable DNA damage sensor activity. Predicted to be involved in mismatch repair and nucleotide-excision repair. Predicted to act upstream of or within DNA damage response. Predicted to be part of XPC complex. Predicted to be active in nucleus. Is expressed in liver. Human ortholog(s) of this gene implicated in pancreatic cancer; serous cystadenocarcinoma; xeroderma pigmentosum; and xeroderma pigmentosum group C. Orthologous to human XPC (XPC complex subunit, DNA damage recognition and repair factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:113032 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| xeroderma pigmentosum group C | Alliance | Xeroderma pigmentosum, group C | 278720 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR018325 | Rad4/PNGase transglutaminase-like fold |
| Domain | IPR018326 | Rad4 beta-hairpin domain 1 |
| Domain | IPR018327 | Rad4 beta-hairpin domain 2 |
| Domain | IPR018328 | Rad4 beta-hairpin domain 3 |
| Family | IPR004583 | DNA repair protein Rad4 |
| Family | IPR018026 | DNA repair protein Rad4-like |
| Homologous_superfamily | IPR036985 | Transglutaminase-like superfamily |
| Homologous_superfamily | IPR038765 | Papain-like cysteine peptidase superfamily |
| Homologous_superfamily | IPR042488 | Rad4, beta-hairpin domain 3 superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | DNA repair protein Rad4 | DNA repair protein Rad4-like | Papain-like cysteine peptidase superfamily | Rad4 beta-hairpin domain 1 | Rad4 beta-hairpin domain 2 | Rad4 beta-hairpin domain 3 | Rad4, beta-hairpin domain 3 superfamily | Rad4/PNGase transglutaminase-like fold | Transglutaminase-like superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PQU6 | InterPro | 844 | |||||||||
| UniProtKB:Q1LVE4 | InterPro | 879 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers