ZFIN is now using GRCz12tu for Genomic Data
Gene
rars1
- ID
- ZDB-GENE-030131-9014
- Name
- arginyl-tRNA synthetase 1
- Symbol
- rars1 Nomenclature History
- Previous Names
-
- rars
- wu:fa96g09
- zgc:86730
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable arginine-tRNA ligase activity. Predicted to be involved in translation. Predicted to act upstream of or within tRNA aminoacylation for protein translation. Predicted to be located in cytosol. Predicted to be part of aminoacyl-tRNA synthetase multienzyme complex. Predicted to be active in cytoplasm. Is expressed in several structures, including digestive system; immature eye; nervous system; pectoral fin bud; and swim bladder. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 9. Orthologous to human RARS1 (arginyl-tRNA synthetase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56050 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Kim et al., 2025
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypomyelinating leukodystrophy 9 | Alliance | Leukodystrophy, hypomyelinating, 9 | 616140 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR001412 | Aminoacyl-tRNA synthetase, class I, conserved site |
| Domain | IPR005148 | Arginyl tRNA synthetase N-terminal domain |
| Domain | IPR008909 | DALR anticodon binding |
| Domain | IPR035684 | Arginyl-tRNA synthetase, catalytic core domain |
| Family | IPR001278 | Arginine-tRNA ligase |
| Homologous_superfamily | IPR009080 | Aminoacyl-tRNA synthetase, class Ia, anticodon-binding |
| Homologous_superfamily | IPR014729 | Rossmann-like alpha/beta/alpha sandwich fold |
| Homologous_superfamily | IPR036695 | Arginyl tRNA synthetase N-terminal domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Aminoacyl-tRNA synthetase, class Ia, anticodon-binding | Aminoacyl-tRNA synthetase, class I, conserved site | Arginine-tRNA ligase | Arginyl-tRNA synthetase, catalytic core domain | Arginyl tRNA synthetase N-terminal domain | Arginyl tRNA synthetase N-terminal domain superfamily | DALR anticodon binding | Rossmann-like alpha/beta/alpha sandwich fold |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7ZVF4 | InterPro | 661 | ||||||||
| UniProtKB:A0A8M6Z3L7 | InterPro | 595 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers