Gene

aldh6a1

ID

ZDB-GENE-030131-9192

Name

aldehyde dehydrogenase 6 family, member A1

Symbol

aldh6a1 Nomenclature History

Previous Names

cb850 (1)
mitochondrial acylating methylmalonate-semialdehyde dehydrogenase
wu:fb03a04
zgc:92082

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to enable methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity. Predicted to be involved in L-valine catabolic process and thymine catabolic process. Predicted to be active in mitochondrion. Is expressed in several structures, including alar plate midbrain region; digestive system; midbrain; musculature system; and ventricular zone. Orthologous to human ALDH6A1 (aldehyde dehydrogenase 6 family member A1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from Thisse et al., 2001

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb850 (6 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With aldh6a1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Methylmalonate semialdehyde dehydrogenase deficiency	614105

Associated With aldh6a1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR016160	Aldehyde dehydrogenase, cysteine active site
Domain	IPR015590	Aldehyde dehydrogenase domain
Family	IPR010061	Methylmalonate-semialdehyde dehydrogenase
Homologous_superfamily	IPR016161	Aldehyde/histidinol dehydrogenase
Homologous_superfamily	IPR016162	Aldehyde dehydrogenase, N-terminal
Homologous_superfamily	IPR016163	Aldehyde dehydrogenase, C-terminal