ZFIN is now using GRCz12tu for Genomic Data
Gene
yrk
- ID
- ZDB-GENE-030131-9517
- Name
- Yes-related kinase
- Symbol
- yrk Nomenclature History
- Previous Names
-
- fj84d04
- wu:fj84d04 (1)
- zgc:92165
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Acts upstream of or within macrophage chemotaxis. Predicted to be active in plasma membrane. Is expressed in blood island; cardiovascular system; head; mesoderm; and post-vent region. Orthologous to human FGR (FGR proto-oncogene, Src family tyrosine kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7159437 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000980 | SH2 domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Domain | IPR035693 | Tyrosine-protein kinase Fgr, SH2 domain |
| Family | IPR050198 | Non-receptor tyrosine kinases involved in cell signaling |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Non-receptor tyrosine kinases involved in cell signaling | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | SH2 domain | SH2 domain superfamily | SH3 domain | SH3-like domain superfamily | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase Fgr, SH2 domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q8AWF1 | InterPro | 525 | ||||||||||||
| UniProtKB:A0AB13A7B9 | InterPro | 528 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
yrk-201
(1)
|
Ensembl | 3,705 nt | ||
| mRNA |
yrk-203
(1)
|
Ensembl | 406 nt | ||
| mRNA |
yrk-204
(1)
|
Ensembl | 3,768 nt | ||
| mRNA |
yrk-205
(1)
|
Ensembl | 567 nt | ||
| mRNA |
yrk-206
(1)
|
Ensembl | 717 nt | ||
| mRNA |
yrk-207
(1)
|
Ensembl | 3,028 nt | ||
| mRNA |
yrk-208
(1)
|
Ensembl | 3,524 nt | ||
| ncRNA |
yrk-004
(1)
|
Ensembl | 539 nt |
Interactions and Pathways
No data available
Plasmids
- Genome Browsers