Gene

fgfr2

ID

ZDB-GENE-030323-1

Name

fibroblast growth factor receptor 2

Symbol

fgfr2 Nomenclature History

Previous Names

fgfr2b (1)
fgfr2c (1)
fc56c05
wu:fc56c05

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Enables fibroblast growth factor binding activity. Acts upstream of or within several processes, including determination of left/right symmetry; nervous system development; and pectoral fin development. Predicted to be located in Golgi apparatus. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including cranium; digestive system; mesoderm; nervous system; and trunk vasculature. Human ortholog(s) of this gene implicated in several diseases, including Beare-Stevenson cutis gyrata syndrome; breast cancer (multiple); gastrointestinal system cancer (multiple); reproductive organ cancer (multiple); and synostosis (multiple). Orthologous to human FGFR2 (fibroblast growth factor receptor 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

62 figures from 38 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cssl:d0138 (23 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 16 figures from 7 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fgfr2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
acrocephalosyndactylia	Alliance	Apert syndrome	101200
Antley-Bixler syndrome without disordered steroidogenesis	Alliance	Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis	207410
Beare-Stevenson cutis gyrata syndrome	Alliance	Beare-Stevenson cutis gyrata syndrome	123790
bent bone dysplasia syndrome 1	Alliance	Bent bone dysplasia syndrome	614592
Crouzon syndrome	Alliance	Crouzon syndrome	123500
Jackson-Weiss syndrome	Alliance	Jackson-Weiss syndrome	123150
lacrimoauriculodentodigital syndrome 1	Alliance	LADD syndrome 1	149730
Pfeiffer syndrome	Alliance	Craniofacial-skeletal-dermatologic dysplasia	101600
Pfeiffer syndrome	Alliance	Pfeiffer syndrome	101600
pre-eclampsia	Alliance	Bent bone dysplasia syndrome	614592
Saethre-Chotzen syndrome	Alliance	Saethre-Chotzen syndrome	101400
stomach cancer	Alliance	Gastric cancer, somatic	613659
		Craniosynostosis, nonspecific
		Scaphocephaly and Axenfeld-Rieger anomaly
		?Scaphocephaly, maxillary retrusion, and impaired intellectual development	609579

Associated With fgfr2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008266	Tyrosine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain	IPR003598	Immunoglobulin subtype 2
Domain	IPR003599	Immunoglobulin domain subtype
Domain	IPR007110	Immunoglobulin-like domain
Domain	IPR013098	Immunoglobulin I-set
Domain	IPR020635	Tyrosine-protein kinase, catalytic domain
Family	IPR016248	Fibroblast growth factor receptor family
Family	IPR050122	Receptor Tyrosine Kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M2BGU2	InterPro	836
UniProtKB:F1RBS5	InterPro	815
UniProtKB:A4QN31	InterPro	728
UniProtKB:A0A8M1NYP8	InterPro	817
UniProtKB:Q8JG38	InterPro	817
UniProtKB:F1RBT3	InterPro	815
UniProtKB:A0AB32TZN5	InterPro	840
UniProtKB:A0AB32U1A3	InterPro	726
UniProtKB:A0AB32U1P5	InterPro	838
UniProtKB:A0AB32U4Z2	InterPro	751

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	fgfr2-201 (1) Ensembl	Ensembl	4,741 nt	Select Tool ZFIN BLAST
mRNA	fgfr2-202 (1) Ensembl	Ensembl	4,885 nt	Select Tool ZFIN BLAST
mRNA	fgfr2-204 (1) Ensembl	Ensembl	3,076 nt	Select Tool ZFIN BLAST
mRNA	fgfr2-205 (1) Ensembl	Ensembl	2,448 nt	Select Tool ZFIN BLAST
mRNA	fgfr2-206 (1) Ensembl	Ensembl	3,224 nt	Select Tool ZFIN BLAST
ncRNA	fgfr2-006 (1) Ensembl	Ensembl	542 nt	Select Tool ZFIN BLAST

Interactions and Pathways

SignaFish

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations