ZFIN is now using GRCz12tu for Genomic Data
Gene
bin1b
- ID
- ZDB-GENE-030425-1
- Name
- bridging integrator 1b
- Symbol
- bin1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable phospholipid binding activity and tau protein binding activity. Acts upstream of or within T-tubule organization and cardiac muscle contraction. Predicted to be located in several cellular components, including T-tubule; axon; and endosome. Predicted to be active in plasma membrane and synaptic vesicle. Is expressed in adaxial cell; cardiovascular system; musculature system; pectoral fin bud; and somite. Used to study centronuclear myopathy 2. Human ortholog(s) of this gene implicated in breast carcinoma; centronuclear myopathy 2; and prostate adenocarcinoma. Orthologous to human BIN1 (bridging integrator 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb57 (14 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| centronuclear myopathy 2 | Alliance | Centronuclear myopathy 2 | 255200 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| centronuclear myopathy 2 | AB + MO2-bin1b | control | Smith et al., 2014 |
| centronuclear myopathy 2 | AB + MO1-bin1b | control | Smith et al., 2014 |
Domain, Family, and Site Summary
Domain Details Per Protein
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
- Genome Browsers