ZFIN is now using GRCz12tu for Genomic Data

Gene

auts2a

ID

ZDB-GENE-030616-571

Name

activator of transcription and developmental regulator AUTS2 a

Symbol

auts2a Nomenclature History

Previous Names

auts2
si:ch211-103d22.3
si:zc103d22.3
wu:fj83b10

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Acts upstream of or within several processes, including action potential initiation; embryonic viscerocranium morphogenesis; and regulation of action potential firing pattern. Is expressed in several structures, including anterior neural keel; anterior neural rod; brain; hindbrain neural keel; and posterior neural rod. Used to study microcephaly and syndromic intellectual disability. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 26. Orthologous to human AUTS2 (activator of transcription and developmental regulator AUTS2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 12 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With auts2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant intellectual developmental disorder 26	Alliance	Intellectual developmental disorder, autosomal dominant 26	615834

Associated With auts2a Via Experimental Models

Human Disease	Fish	Conditions	Citations
microcephaly	WT + MO3-auts2a	standard conditions	Beunders et al., 2013
microcephaly	WT + MO4-auts2a	standard conditions	Beunders et al., 2013
syndromic intellectual disability	WT + MO3-auts2a	standard conditions	Beunders et al., 2013
syndromic intellectual disability	WT + MO4-auts2a	standard conditions	Beunders et al., 2013

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR023246	Autism susceptibility gene 2 protein

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M9QL45	InterPro	1276
UniProtKB:E7F4D0	InterPro	1278
UniProtKB:A0A8M9PS82	InterPro	1104
UniProtKB:F1QRM5	InterPro	1126
UniProtKB:A0A2R8RIS2	InterPro	810
UniProtKB:A0A8M6Z8W2	InterPro	1271
UniProtKB:A0A1X9RK91	InterPro	811
UniProtKB:A0A1X9RK86	InterPro	1277
UniProtKB:A0A8M6Z317	InterPro	1277
UniProtKB:A0A1X9RK87	InterPro	1277
UniProtKB:A0A8M3AWT8	InterPro	1128
UniProtKB:A0AC58GMH5	InterPro	1276
UniProtKB:A0AC58GMI7	InterPro	1274
UniProtKB:A0AC58GMI9	InterPro	1276
UniProtKB:A0AC58GMJ0	InterPro	1276
UniProtKB:A0AC58GMJ1	InterPro	1273
UniProtKB:A0AC58GMJ4	InterPro	1275
UniProtKB:A0AC58GMJ6	InterPro	1275
UniProtKB:A0AC58GMJ7	InterPro	1275
UniProtKB:A0AC58GMJ8	InterPro	1274
UniProtKB:A0AC58GMK0	InterPro	1274
UniProtKB:A0AC58GMK1	InterPro	1269
UniProtKB:A0AC58GMK2	InterPro	1274
UniProtKB:A0AC58GMK3	InterPro	1275
UniProtKB:A0AC58GMK4	InterPro	1118
UniProtKB:A0AC58GMK5	InterPro	1275
UniProtKB:A0AC58GMK6	InterPro	1275
UniProtKB:A0AC58GMK8	InterPro	1274
UniProtKB:A0AC58GMK9	InterPro	1266
UniProtKB:A0AC58GML1	InterPro	1117
UniProtKB:A0AC58GML2	InterPro	1124
UniProtKB:A0AC58GML3	InterPro	1119
UniProtKB:A0AC58GML4	InterPro	1267
UniProtKB:A0AC58GML5	InterPro	1125
UniProtKB:A0AC58GML6	InterPro	1268
UniProtKB:A0AC58GML7	InterPro	1050
UniProtKB:A0AC58GML8	InterPro	1275
UniProtKB:A0AC58GMM0	InterPro	808
UniProtKB:A0AC58GMM1	InterPro	1118
UniProtKB:A0AC58GMM2	InterPro	1267
UniProtKB:A0AC58GMM3	InterPro	1043
UniProtKB:A0AC58GMM4	InterPro	808
UniProtKB:A0AC58GMM5	InterPro	1051
UniProtKB:A0AC58GMM6	InterPro	809
UniProtKB:A0AC58GMM7	InterPro	1126
UniProtKB:A0AC58GMM8	InterPro	801
UniProtKB:A0AC58GMM9	InterPro	1268
UniProtKB:A0AC58GMN0	InterPro	1050
UniProtKB:A0AC58GMN1	InterPro	1043
UniProtKB:A0AC58GMN2	InterPro	809
UniProtKB:A0AC58GMN3	InterPro	1044
UniProtKB:A0AC58GMN4	InterPro	802
UniProtKB:A0AC58GMN5	InterPro	801
UniProtKB:A0AC58GMN7	InterPro	802
UniProtKB:A0AC58GMP2	InterPro	1042
UniProtKB:A0AC58GMP8	InterPro	1049
UniProtKB:A0AC58GMT1	InterPro	1275
UniProtKB:A0AC58GMT9	InterPro	1125

Transcripts

Genome Browsers

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	auts2a-201 (1) Ensembl	Ensembl	4,086 nt	Select Tool ZFIN BLAST
mRNA	auts2a-202 (1) Ensembl	Ensembl	4,714 nt	Select Tool ZFIN BLAST
mRNA	auts2a-203 (1) Ensembl	Ensembl	4,214 nt	Select Tool ZFIN BLAST
mRNA	auts2a-204 (1) Ensembl	Ensembl	3,533 nt	Select Tool ZFIN BLAST
mRNA	auts2a-205 (1) Ensembl	Ensembl	4,122 nt	Select Tool ZFIN BLAST
mRNA	auts2a-206 (1) Ensembl	Ensembl	3,039 nt	Select Tool ZFIN BLAST
mRNA	auts2a-207 (1) Ensembl	Ensembl	5,319 nt	Select Tool ZFIN BLAST
mRNA	auts2a-208 (1) Ensembl	Ensembl	4,711 nt	Select Tool ZFIN BLAST
mRNA	auts2a-209 (1) Ensembl	Ensembl	4,843 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Genome Browsers

NCBI Map Viewer

ZFIN

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations