gh1

ID

ZDB-GENE-030725-2

Name

growth hormone 1

Symbol

gh1 Nomenclature History

Previous Names

gh (1)
ghl

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Enables growth hormone activity and growth hormone receptor binding activity. Acts upstream of or within adipose tissue development and positive regulation of lipid catabolic process. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including adenohypophyseal placode; bone tissue; hematopoietic multipotent progenitor cell; hypophysis; and male organism. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); autoimmune disease of endocrine system (multiple); diabetic retinopathy; isolated growth hormone deficiency (multiple); and progeria. Orthologous to several human genes including GH1 (growth hormone 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

97 figures from 61 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 15 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gh1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
isolated growth hormone deficiency type IA	Alliance	Growth hormone deficiency, isolated, type IA	262400
isolated growth hormone deficiency type IB	Alliance	Growth hormone deficiency, isolated, type IB	612781
isolated growth hormone deficiency type II	Alliance	Growth hormone deficiency, isolated, type II	173100
		Kowarski syndrome	262650

Associated With gh1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018116	Somatotropin hormone, conserved site
Family	IPR001400	Somatotropin/prolactin
Family	IPR034975	Somatotropin
Homologous_superfamily	IPR009079	Four-helical cytokine-like, core