stat5a

ID

ZDB-GENE-030820-2

Name

signal transducer and activator of transcription 5a

Symbol

stat5a Nomenclature History

Previous Names

stat5.1
stat5b
sb:eu615

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Enables DNA binding activity and DNA-binding transcription factor activity. Acts upstream of or within several processes, including cell surface receptor signaling pathway via JAK-STAT; hemopoiesis; and regulation of hemopoiesis. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in cytoplasm and nucleus. Is expressed in adaxial cell; female organism; liver; and telencephalon. Used to study growth hormone insensitivity syndrome with immune dysregulation 1. Human ortholog(s) of this gene implicated in colon adenocarcinoma; colorectal adenocarcinoma; growth hormone insensitivity syndrome with immune dysregulation 1; and growth hormone insensitivity syndrome with immune dysregulation 2. Orthologous to several human genes including STAT5B (signal transducer and activator of transcription 5B).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 11 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu615 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 11 figures from 7 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With stat5a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
growth hormone insensitivity syndrome with immune dysregulation 1	Alliance	Growth hormone insensitivity with immune dysregulation 1, autosomal recessive	245590
growth hormone insensitivity syndrome with immune dysregulation 2	Alliance	Growth hormone insensitivity with immune dysregulation 2, autosomal dominant	618985

Associated With stat5a Via Experimental Models

Human Disease	Fish	Conditions	Citations
growth hormone insensitivity syndrome with immune dysregulation 1	stat5a^{mdu022/mdu022}	standard conditions	Heidary et al., 2023

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000980	SH2 domain
Domain	IPR013799	STAT transcription factor, protein interaction
Domain	IPR013800	STAT transcription factor, all-alpha domain
Domain	IPR013801	STAT transcription factor, DNA-binding
Domain	IPR035858	STAT5a/5b, DNA-binding domain
Domain	IPR046994	STAT5a/5b, coiled-coil domain
Domain	IPR048988	Signal transducer and activator of transcription, linker domain
Family	IPR001217	Transcription factor STAT
Homologous_superfamily	IPR008967	p53-like transcription factor, DNA-binding domain superfamily
Homologous_superfamily	IPR012345	STAT transcription factor, DNA-binding, N-terminal
Homologous_superfamily	IPR015988	STAT transcription factor, coiled coil
Homologous_superfamily	IPR036535	STAT transcription factor, N-terminal domain superfamily
Homologous_superfamily	IPR036860	SH2 domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:Q68SP3	InterPro	785
UniProtKB:A0AB32TFF3	InterPro	1913
UniProtKB:A0AC58IGL4	InterPro	785
UniProtKB:A0AC58IGL7	InterPro	785
UniProtKB:A0AC58IGM1	InterPro	785
UniProtKB:A0AC58IGN3	InterPro	785
UniProtKB:A0AC58IGN5	InterPro	785
UniProtKB:A0AC58IGP2	InterPro	785
UniProtKB:A0AC58IGR3	InterPro	785
UniProtKB:A0AC58IGS4	InterPro	785
UniProtKB:A0AC58IGS6	InterPro	785