ZFIN is now using GRCz12tu for Genomic Data
Gene
casp9
- ID
- ZDB-GENE-030825-5
- Name
- caspase 9, apoptosis-related cysteine peptidase
- Symbol
- casp9 Nomenclature History
- Previous Names
-
- im:7136887
- zgc:101776
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable cysteine-type endopeptidase activity. Acts upstream of or within several processes, including positive regulation of apoptotic process; regulation of collateral sprouting in absence of injury; and renal filtration. Predicted to be active in cytosol. Is expressed in several structures, including gut; liver; male organism; muscle; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including Parkinson's disease; colorectal cancer; lung non-small cell carcinoma; pancreatic cancer; and type 2 diabetes mellitus. Orthologous to human CASP9 (caspase 9).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 46 figures from 38 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7136887 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016129 | Peptidase family C14A, His active site |
| Active_site | IPR033139 | Peptidase family C14A, cysteine active site |
| Domain | IPR001309 | Peptidase C14, p20 domain |
| Domain | IPR001315 | CARD domain |
| Domain | IPR002138 | Peptidase C14, caspase non-catalytic subunit p10 |
| Domain | IPR011600 | Peptidase C14, caspase domain |
| Domain | IPR015917 | Peptidase C14A, caspase catalytic domain |
| Domain | IPR042147 | CASP9, CARD domain |
| Family | IPR002398 | Peptidase C14 family |
| Homologous_superfamily | IPR011029 | Death-like domain superfamily |
| Homologous_superfamily | IPR029030 | Caspase-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | CARD domain | CASP9, CARD domain | Caspase-like domain superfamily | Death-like domain superfamily | Peptidase C14A, caspase catalytic domain | Peptidase C14, caspase domain | Peptidase C14, caspase non-catalytic subunit p10 | Peptidase C14 family | Peptidase C14, p20 domain | Peptidase family C14A, cysteine active site | Peptidase family C14A, His active site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QSB1 | InterPro | 436 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers