Gene
birc2
- ID
- ZDB-GENE-030825-6
- Name
- baculoviral IAP repeat containing 2
- Symbol
- birc2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process and ubiquitin protein ligase activity. Predicted to be involved in negative regulation of programmed cell death; positive regulation of protein ubiquitination; and regulation of cell cycle. Predicted to act upstream of or within apoptotic process and regulation of apoptotic process. Predicted to be active in cytoplasm and nucleus. Is expressed in dorsal aorta; intersegmental vessel; and posterior cardinal vein. Human ortholog(s) of this gene implicated in breast cancer; carcinoma (multiple); and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue. Orthologous to several human genes including BIRC2 (baculoviral IAP repeat containing 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6903716 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001315 | CARD domain |
| Domain | IPR001841 | Zinc finger, RING-type |
| Domain | IPR041933 | BIRC2/BIRC3, UBA domain |
| Domain | IPR048875 | BIRC2/3-like, UBA domain |
| Family | IPR050784 | Inhibitor of Apoptosis |
| Homologous_superfamily | IPR011029 | Death-like domain superfamily |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Repeat | IPR001370 | BIR repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | BIRC2/3-like, UBA domain | BIRC2/BIRC3, UBA domain | BIR repeat | CARD domain | Death-like domain superfamily | Inhibitor of Apoptosis | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A2R8QDZ3 | InterPro | 633 | ||||||||
| UniProtKB:Q7T0K2 | InterPro | 647 | ||||||||
| UniProtKB:Q8UWD2 | InterPro | 628 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available