erbb4b

ID

ZDB-GENE-030918-5

Name

erb-b2 receptor tyrosine kinase 4b

Symbol

erbb4b Nomenclature History

Previous Names

erbb4l
si:dkeyp-52f4.1
zmp:0000000963

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Is expressed in heart; muscle; nervous system; and trunk. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 19; colorectal cancer; esophagus squamous cell carcinoma; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human ERBB4 (erb-b2 receptor tyrosine kinase 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With erbb4b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
amyotrophic lateral sclerosis type 19	Alliance	Amyotrophic lateral sclerosis 19	615515

Associated With erbb4b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008266	Tyrosine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000494	Receptor L-domain
Domain	IPR000719	Protein kinase domain
Domain	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain	IPR006211	Furin-like cysteine-rich domain
Domain	IPR020635	Tyrosine-protein kinase, catalytic domain
Domain	IPR032778	Growth factor receptor domain 4
Domain	IPR049328	Epidermal growth factor receptor-like, transmembrane-juxtamembrane segment
Family	IPR016245	Tyrosine protein kinase, EGF/ERB/XmrK receptor
Family	IPR050122	Receptor Tyrosine Kinase
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR036941	Receptor L-domain superfamily
Homologous_superfamily	IPR044912	Epidermal growth factor receptor, juxtamembrane domain
Repeat	IPR006212	Furin-like repeat

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M3BCL4	InterPro	1384
UniProtKB:A0AC58GH52	InterPro	1398
UniProtKB:A0AC58GH53	InterPro	1383
UniProtKB:A0AC58GH54	InterPro	1407
UniProtKB:A0AB32U1Z7	InterPro	1408
UniProtKB:A0AC58GH67	InterPro	1397
UniProtKB:A0AC58GH68	InterPro	1316
UniProtKB:A0AC58GH69	InterPro	1326
UniProtKB:A0AC58GH70	InterPro	1374
UniProtKB:A0AC58GH71	InterPro	1315
UniProtKB:A0AC58GH74	InterPro	1063
UniProtKB:A0AC58GH75	InterPro	1316
UniProtKB:A0AC58GH76	InterPro	1326
UniProtKB:A0AC58GH79	InterPro	1064
UniProtKB:A0AC58GH81	InterPro	1315
UniProtKB:A0AC58GH93	InterPro	1373
UniProtKB:A0AC58GH94	InterPro	1340
UniProtKB:A0AC58GHB0	InterPro	1340