ZFIN is now using GRCz12tu for Genomic Data
Gene
itga5
- ID
- ZDB-GENE-031116-52
- Name
- integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
- Symbol
- itga5 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables fibronectin binding activity and protein heterodimerization activity. Acts upstream of or within several processes, including camera-type eye development; chordate embryonic development; and circulatory system development. Predicted to be located in membrane. Predicted to be part of integrin complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including cardiovascular system; ectoderm; head; mesoderm; and somite. Orthologous to human ITGA5 (integrin subunit alpha 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 23 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb665 (17 images)
Wild Type Expression Summary
- All Phenotype Data
- 25 figures from 12 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018184 | Integrin alpha chain, C-terminal cytoplasmic region, conserved site |
| Domain | IPR013649 | Integrin alpha, first immunoglubulin-like domain |
| Domain | IPR048285 | Integrin alpha, second immunoglobulin-like domain |
| Domain | IPR048286 | Integrin alpha, third immunoglobulin-like domain |
| Family | IPR000413 | Integrin alpha chain |
| Homologous_superfamily | IPR028994 | Integrin alpha, N-terminal |
| Homologous_superfamily | IPR032695 | Integrin domain superfamily |
| Repeat | IPR013517 | FG-GAP repeat |
| Repeat | IPR013519 | Integrin alpha beta-propellor |
Domain Details Per Protein
| Protein | Additional Resources | Length | FG-GAP repeat | Integrin alpha beta-propellor | Integrin alpha chain | Integrin alpha chain, C-terminal cytoplasmic region, conserved site | Integrin alpha, first immunoglubulin-like domain | Integrin alpha, N-terminal | Integrin alpha, second immunoglobulin-like domain | Integrin alpha, third immunoglobulin-like domain | Integrin domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q5I2A9 | InterPro | 1053 | |||||||||
| UniProtKB:Q6QAF3 | InterPro | 1035 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers