Gene
gpc3
- ID
- ZDB-GENE-031212-1
- Name
- glypican 3
- Symbol
- gpc3 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Acts upstream of or within cell migration involved in gastrulation and negative regulation of canonical Wnt signaling pathway. Predicted to be located in side of membrane. Predicted to be active in cell surface and plasma membrane. Is expressed in intestine; liver; and midbrain. Human ortholog(s) of this gene implicated in Simpson-Golabi-Behmel syndrome type 1; hepatocellular carcinoma; and nephroblastoma. Orthologous to human GPC3 (glypican 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nephroblastoma | Alliance | Wilms tumor, somatic | 194070 |
| Simpson-Golabi-Behmel syndrome type 1 | Alliance | Simpson-Golabi-Behmel syndrome, type 1 | 312870 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR001863 | Glypican |
Domain Details Per Protein
| Protein | Additional Resources | Length | Glypican |
|---|---|---|---|
| UniProtKB:Q6V9Y8 | InterPro | 590 |
Interactions and Pathways
Plasmids
No data available