Gene
tirap
- ID
- ZDB-GENE-040219-4
- Name
- toll-interleukin 1 receptor (TIR) domain containing adaptor protein
- Symbol
- tirap Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable Toll-like receptor 2 binding activity and Toll-like receptor 4 binding activity. Predicted to be involved in positive regulation of canonical NF-kappaB signal transduction; positive regulation of cytokine production; and toll-like receptor 4 signaling pathway. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in malaria and tuberculosis. Orthologous to human TIRAP (TIR domain containing adaptor protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap | Toll/interleukin-1 receptor homology (TIR) domain | Toll/interleukin-1 receptor homology (TIR) domain superfamily |
|---|---|---|---|---|---|
| UniProtKB:A0A8M6Z2S6 | InterPro | 243 | |||
| UniProtKB:A0A8M1REJ6 | InterPro | 226 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available