Gene

lipca

ID

ZDB-GENE-040426-1361

Name

lipase, hepatic a

Symbol

lipca Nomenclature History

Previous Names

lipc
zgc:64081

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to enable apolipoprotein binding activity; lipoprotein lipase activity; and phospholipase A1 activity. Acts upstream of or within response to hormone. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including heart; integument; lens; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; familial combined hyperlipidemia; glucose metabolism disease (multiple); obesity; and peripheral vascular disease. Orthologous to human LIPC (lipase C, hepatic type).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

15 figures from 11 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:64081 (2 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lipca Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
type 2 diabetes mellitus	Alliance	{Diabetes mellitus, noninsulin-dependent}	125853
		Hepatic lipase deficiency	614025
		[High density lipoprotein cholesterol level QTL 12]	612797

Associated With lipca Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001024	PLAT/LH2 domain
Domain	IPR013818	Lipase
Domain	IPR033906	Lipase, N-terminal
Family	IPR000734	Triacylglycerol lipase family
Family	IPR002333	Hepatic lipase
Family	IPR016272	Lipase, LIPH-type
Homologous_superfamily	IPR029058	Alpha/Beta hydrolase fold
Homologous_superfamily	IPR036392	PLAT/LH2 domain superfamily