Gene
shmt1
- ID
- ZDB-GENE-040426-1558
- Name
- serine hydroxymethyltransferase 1 (soluble)
- Symbol
- shmt1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Enables glycine hydroxymethyltransferase activity. Predicted to be involved in glycine biosynthetic process from serine and tetrahydrofolate metabolic process. Located in cytosol and nucleus. Is expressed in several structures, including digestive system; immature eye; midbrain; neural tube; and oocyte. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human SHMT1 (serine hydroxymethyltransferase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6910517 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR019798 | Serine hydroxymethyltransferase, pyridoxal phosphate binding site |
| Domain | IPR039429 | Serine hydroxymethyltransferase-like domain |
| Family | IPR001085 | Serine hydroxymethyltransferase |
| Family | IPR049943 | Serine hydroxymethyltransferase-like |
| Homologous_superfamily | IPR015421 | Pyridoxal phosphate-dependent transferase, major domain |
| Homologous_superfamily | IPR015422 | Pyridoxal phosphate-dependent transferase, small domain |
| Homologous_superfamily | IPR015424 | Pyridoxal phosphate-dependent transferase |
Domain Details Per Protein
| Protein | Additional Resources | Length | Pyridoxal phosphate-dependent transferase | Pyridoxal phosphate-dependent transferase, major domain | Pyridoxal phosphate-dependent transferase, small domain | Serine hydroxymethyltransferase | Serine hydroxymethyltransferase-like | Serine hydroxymethyltransferase-like domain | Serine hydroxymethyltransferase, pyridoxal phosphate binding site |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7SXN1 | InterPro | 481 |
Interactions and Pathways
No data available
Plasmids
No data available