guca1ab.1

ID

ZDB-GENE-040426-1577

Name

guanylate cyclase activator 1Ab.1

Symbol

guca1ab.1 Nomenclature History

Previous Names

gcap5 (1)
guca1e (1)
zgc:66243

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Enables calcium sensitive guanylate cyclase activator activity; identical protein binding activity; and metal ion binding activity. Predicted to be involved in regulation of signal transduction and visual perception. Predicted to be active in cone photoreceptor outer segment and photoreceptor inner segment. Is expressed in eye and retina. Human ortholog(s) of this gene implicated in cone-rod dystrophy 14. Orthologous to human GUCA1A (guanylate cyclase activator 1A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With guca1ab.1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
cone-rod dystrophy 14	Alliance	Cone dystrophy-3	602093
cone-rod dystrophy 14	Alliance	Cone-rod dystrophy 14	602093

Associated With guca1ab.1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR018247	EF-Hand 1, calcium-binding site
Domain	IPR002048	EF-hand domain
Family	IPR028846	Recoverin family
Homologous_superfamily	IPR011992	EF-hand domain pair