ZFIN is now using GRCz12tu for Genomic Data
Gene
grhprb
- ID
- ZDB-GENE-040426-1847
- Name
- glyoxylate reductase/hydroxypyruvate reductase b
- Symbol
- grhprb Nomenclature History
- Previous Names
-
- fb80f04
- wu:fb80f04
- zgc:77636
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable glyoxylate reductase (NADPH) activity and hydroxypyruvate reductase (NADH) activity. Predicted to be involved in monocarboxylic acid metabolic process. Predicted to be active in cytosol. Is expressed in hypural; liver; pronephric duct; pronephros; and yolk syncytial layer. Human ortholog(s) of this gene implicated in primary hyperoxaluria and primary hyperoxaluria type 2. Orthologous to human GRHPR (glyoxylate and hydroxypyruvate reductase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77636 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary hyperoxaluria type 2 | Alliance | Hyperoxaluria, primary, type II | 260000 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR029752 | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 |
| Conserved_site | IPR029753 | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site |
| Domain | IPR006139 | D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain |
| Domain | IPR006140 | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain |
| Family | IPR050223 | D-isomer specific 2-hydroxyacid dehydrogenase |
| Homologous_superfamily | IPR036291 | NAD(P)-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | D-isomer specific 2-hydroxyacid dehydrogenase | D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 | NAD(P)-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:E9QCX2 | InterPro | 351 | ||||||
| UniProtKB:Q6P0V7 | InterPro | 336 | ||||||
| UniProtKB:F1QYH7 | InterPro | 361 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
grhprb-201
(1)
|
Ensembl | 1,276 nt | ||
| mRNA |
grhprb-202
(1)
|
Ensembl | 733 nt | ||
| mRNA |
grhprb-205
(1)
|
Ensembl | 2,454 nt | ||
| ncRNA |
grhprb-004
(1)
|
Ensembl | 426 nt | ||
| ncRNA |
grhprb-006
(1)
|
Ensembl | 1,068 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers