Gene

acadm

ID

ZDB-GENE-040426-1945

Name

acyl-CoA dehydrogenase medium chain

Symbol

acadm Nomenclature History

Previous Names

MCAD (1)
fb53e01 (1)
wu:fb53e01 (1)
zgc:111905
zgc:56101 (1)
zgc:76911 (1)

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to enable medium-chain fatty acyl-CoA dehydrogenase activity. Predicted to be involved in medium-chain fatty acid catabolic process. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in female organism and liver. Human ortholog(s) of this gene implicated in medium chain acyl-CoA dehydrogenase deficiency. Orthologous to human ACADM (acyl-CoA dehydrogenase medium chain).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 7 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:56101 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With acadm Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
medium chain acyl-CoA dehydrogenase deficiency	Alliance	Acyl-CoA dehydrogenase, medium chain, deficiency of	201450

Associated With acadm Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR006089	Acyl-CoA dehydrogenase, conserved site
Domain	IPR006091	Acyl-CoA oxidase/dehydrogenase, middle domain
Domain	IPR009075	Acyl-CoA dehydrogenase/oxidase, C-terminal
Domain	IPR013786	Acyl-CoA dehydrogenase/oxidase, N-terminal
Family	IPR034180	Medium-chain specific acyl-CoA dehydrogenase
Family	IPR050741	Acyl-CoA dehydrogenase
Homologous_superfamily	IPR009100	Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily
Homologous_superfamily	IPR036250	Acyl-CoA dehydrogenase-like, C-terminal
Homologous_superfamily	IPR037069	Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily
Homologous_superfamily	IPR046373	Acyl-CoA oxidase/dehydrogenase, middle domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length	Acyl-CoA dehydrogenase	Acyl-CoA dehydrogenase, conserved site	Acyl-CoA dehydrogenase-like, C-terminal	Acyl-CoA dehydrogenase/oxidase, C-terminal	Acyl-CoA dehydrogenase/oxidase, N-terminal	Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily	Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily	Acyl-CoA oxidase/dehydrogenase, middle domain	Acyl-CoA oxidase/dehydrogenase, middle domain superfamily	Medium-chain specific acyl-CoA dehydrogenase
UniProtKB:A2CG95	InterPro	426

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	acadm-201 (1) Ensembl	Ensembl	1,662 nt	Select Tool ZFIN BLAST
mRNA	acadm-204 (1) Ensembl	Ensembl	759 nt	Select Tool ZFIN BLAST
ncRNA	acadm-003 (1) Ensembl	Ensembl	485 nt	Select Tool ZFIN BLAST
ncRNA	acadm-004 (1) Ensembl	Ensembl	656 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations