map2k1

ID

ZDB-GENE-040426-2759

Name

mitogen-activated protein kinase kinase 1

Symbol

map2k1 Nomenclature History

Previous Names

mek1 (1)
si:ch211-242m18.2
wu:fj56a12
wu:fj61b01 (1)
zgc:56557

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable MAP kinase kinase activity. Predicted to be involved in MAPK cascade. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in several cellular components, including centrosome; endosome; and focal adhesion. Is expressed in cardiac ventricle. Human ortholog(s) of this gene implicated in carcinoma (multiple); cardiofaciocutaneous syndrome 3; high grade glioma; and melorheostosis. Orthologous to human MAP2K1 (mitogen-activated protein kinase kinase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With map2k1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
cardiofaciocutaneous syndrome 3	Alliance	Cardiofaciocutaneous syndrome 3	615279
melorheostosis	Alliance	Melorheostosis, isolated, somatic mosaic	155950

Associated With map2k1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Family	IPR050915	MAP kinase kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily