Gene
vldlr
- ID
- ZDB-GENE-040426-803
- Name
- very low density lipoprotein receptor
- Symbol
- vldlr Nomenclature History
- Previous Names
-
- lr8 (1)
- zgc:55792
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable apolipoprotein binding activity. Predicted to be involved in animal organ development. Predicted to act upstream of or within endocytosis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in axis; central nervous system; immature eye; pronephric duct; and retinal ganglion cell layer. Human ortholog(s) of this gene implicated in Alzheimer's disease; cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1; and dementia. Orthologous to human VLDLR (very low density lipoprotein receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55792 (8 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1 | Alliance | Cerebellar hypoplasia, impaired intellectual development, and dysequilibrium syndrome 1 | 224050 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Conserved_site | IPR023415 | Low-density lipoprotein (LDL) receptor class A, conserved site |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR049883 | NOTCH1 EGF-like calcium-binding domain |
| Family | IPR051221 | Low-density lipoprotein receptor-related |
| Homologous_superfamily | IPR011042 | Six-bladed beta-propeller, TolB-like |
| Homologous_superfamily | IPR036055 | LDL receptor-like superfamily |
| PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
| Repeat | IPR000033 | LDLR class B repeat |
| Repeat | IPR002172 | Low-density lipoprotein (LDL) receptor class A repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | LDLR class B repeat | LDL receptor-like superfamily | Low-density lipoprotein (LDL) receptor class A, conserved site | Low-density lipoprotein (LDL) receptor class A repeat | Low-density lipoprotein receptor-related | NOTCH1 EGF-like calcium-binding domain | Six-bladed beta-propeller, TolB-like |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B1M8 | InterPro | 877 | |||||||||||
| UniProtKB:A0A8M9PTE7 | InterPro | 856 | |||||||||||
| UniProtKB:A0A8M2B226 | InterPro | 874 | |||||||||||
| UniProtKB:E7FF13 | InterPro | 866 | |||||||||||
| UniProtKB:A0A0R4IGN2 | InterPro | 863 | |||||||||||
| UniProtKB:E9QBA5 | InterPro | 842 | |||||||||||
| UniProtKB:A0AB32U266 | InterPro | 839 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
vldlr-201
(1)
|
Ensembl | 3,751 nt | ||
| mRNA |
vldlr-203
(1)
|
Ensembl | 3,496 nt | ||
| mRNA |
vldlr-205
(1)
|
Ensembl | 4,074 nt | ||
| mRNA |
vldlr-206
(1)
|
Ensembl | 4,053 nt | ||
| mRNA |
vldlr-207
(1)
|
Ensembl | 4,132 nt | ||
| ncRNA |
vldlr-002
(1)
|
Ensembl | 921 nt | ||
| ncRNA |
vldlr-003
(1)
|
Ensembl | 752 nt |
Interactions and Pathways
No data available
Plasmids
No data available