ZFIN is now using GRCz12tu for Genomic Data
Gene
irs2a
- ID
- ZDB-GENE-040426-975
- Name
- insulin receptor substrate 2a
- Symbol
- irs2a Nomenclature History
- Previous Names
-
- zgc:56306
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable transmembrane receptor protein tyrosine kinase adaptor activity. Acts upstream of or within response to hypoxia. Predicted to be active in cytosol and plasma membrane. Is expressed in germ ring; head; and liver. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human IRS2 (insulin receptor substrate 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| type 2 diabetes mellitus | Alliance | {Diabetes mellitus, noninsulin-dependent} | 125853 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Insulin receptor substrate | IRS-type PTB domain | PH-like domain superfamily | Pleckstrin homology domain |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PD89 | InterPro | 1086 | ||||
| UniProtKB:Q7ZU74 | InterPro | 1032 | ||||
| UniProtKB:A0AC58H7K0 | InterPro | 1075 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers