ZFIN is now using GRCz12tu for Genomic Data
Gene
pou1f1
- ID
- ZDB-GENE-040630-7
- Name
- POU class 1 homeobox 1
- Symbol
- pou1f1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within cell fate specification. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in adenohypophyseal placode; adenohypophysis; brain; head; and hypophysis. Human ortholog(s) of this gene implicated in combined or isolated pituitary hormone deficiency 1 and pituitary gland disease. Orthologous to human POU1F1 (POU class 1 homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 29 figures from 20 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu451 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Phenotype Annotation (1994-2006)
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| combined or isolated pituitary hormone deficiency 1 | Alliance | Pituitary hormone deficiency, combined or isolated, 1 | 613038 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017970 | Homeobox, conserved site |
| Domain | IPR000327 | POU-specific domain |
| Domain | IPR001356 | Homeodomain |
| Domain | IPR013847 | POU domain |
| Family | IPR050255 | POU domain transcription factor |
| Homologous_superfamily | IPR009057 | Homedomain-like superfamily |
| Homologous_superfamily | IPR010982 | Lambda repressor-like, DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Lambda repressor-like, DNA-binding domain superfamily | POU domain | POU domain transcription factor | POU-specific domain |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6TGI4 | InterPro | 350 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pou1f1-201
(1)
|
Ensembl | 1,170 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers